SLC22A17 Antibody (PACO18896)
- SKU:
- PACO18896
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC22A17 Antibody (PACO18896) |
| Antibody SKU: | PACO18896 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human SLC22A17 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18896(SLC22A17 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. |
| Synonyms: | solute carrier family 22, member 17 |
| UniProt Protein Function: | SLC22A17: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: integral to plasma membrane; vacuolar membrane Molecular Function:transmembrane receptor activity; transmembrane transporter activity Biological Process: cellular iron ion homeostasis; siderophore transport; ion transport; signal transduction; transmembrane transport |
| UniProt Code: | Q8WUG5 |
| NCBI GenInfo Identifier: | 27805426 |
| NCBI Gene ID: | 51310 |
| NCBI Accession: | Q8WUG5.1 |
| UniProt Related Accession: | Q8WUG5 |
| Molecular Weight: | |
| NCBI Full Name: | Solute carrier family 22 member 17 |
| NCBI Synonym Full Names: | solute carrier family 22 member 17 |
| NCBI Official Symbol: | SLC22A17 |
| NCBI Official Synonym Symbols: | BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3 |
| NCBI Protein Information: | solute carrier family 22 member 17 |
| UniProt Protein Name: | Solute carrier family 22 member 17 |
| UniProt Synonym Protein Names: | 24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NgalR |
| UniProt Gene Name: | SLC22A17 |
| UniProt Entry Name: | S22AH_HUMAN |
| Antibodies |
| SLC22A17 Antibody (PACO01781) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Human TP53 antibody(p53 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
SPEF2 Antibody
Overview Product Name:SPEF2 AntibodyProduct Code:PACO64977Size:50µLTarget Names:SPEF2Species Reactivity:HumanHos