SLC17A3 Antibody (PACO29920)
- SKU:
- PACO29920
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SLC17A3 Antibody (PACO29920) |
| Antibody SKU: | PACO29920 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sodium-dependent phosphate transport protein 4 protein (1-125AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO29920 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO29920 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. |
| Synonyms: | Sodium-dependent phosphate transport protein 4 (Na(+)/PI cotransporter 4) (Sodium/phosphate cotransporter 4) (Solute carrier family 17 member 3), SLC17A3, NPT4 |
| UniProt Protein Function: | Function: Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na+ cotransport. Ref.7Subcellular location: Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.6 Ref.7. Isoform 2: Cell membrane; Multi-pass membrane protein Ref.6 Ref.7. Tissue specificity: Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level). Ref.1 Ref.7Polymorphism: Genetic variations in SLC17A3 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 4 (UAQTL4) [MIM:612671]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia.Sequence similarities: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.Sequence caution: The sequence AAB53423.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012] |
| UniProt Code: | O00476 |
| NCBI GenInfo Identifier: | 148743791 |
| NCBI Gene ID: | 10786 |
| NCBI Accession: | NP_001091956.1 |
| UniProt Secondary Accession: | O00476 |
| UniProt Related Accession: | O00476 |
| Molecular Weight: | 46 kDa |
| NCBI Full Name: | sodium-dependent phosphate transport protein 4 isoform a |
| NCBI Synonym Full Names: | solute carrier family 17 member 3 |
| NCBI Official Symbol: | SLC17A3 |
| NCBI Official Synonym Symbols: | NPT4; GOUT4; UAQTL4 |
| NCBI Protein Information: | sodium-dependent phosphate transport protein 4 |
| UniProt Protein Name: | Sodium-dependent phosphate transport protein 4 |
| UniProt Synonym Protein Names: | Na(+)/PI cotransporter 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 member 3 |
| Protein Family: | Sodium-dependent phosphate transport protein |
| UniProt Gene Name: | SLC17A3 |
| UniProt Entry Name: | NPT4_HUMAN |
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