SKOR2 Antibody (PACO61931)
- SKU:
- PACO61931
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SKOR2 Antibody (PACO61931) |
| Antibody SKU: | PACO61931 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Peptide sequence from Human SKI family transcriptional corepressor 2 protein (19-36AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO61931 diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | Immunofluorescence staining of K562 cells with PACO61931 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | IHC image of PACO61931 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-β antagonist in the nervous system. |
| Synonyms: | SKI family transcriptional corepressor 2 (Functional Smad-suppressing element on chromosome 18) (Fussel-18) (LBX1 corepressor 1-like protein) (Ladybird homeobox corepressor 1-like protein), SKOR2, CORL2 FUSSEL18 |
| UniProt Protein Function: | FUSSEL18: Exhibits transcriptional repressor activity. Acts as a TGF-beta antagonist in the nervous system. Belongs to the SKI family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 18q21.1Cellular Component: cytoplasm; nucleusMolecular Function: SMAD binding; transcription corepressor activityBiological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q2VWA4 |
| NCBI GenInfo Identifier: | 189082904 |
| NCBI Gene ID: | 652991 |
| NCBI Accession: | Q2VWA4.2 |
| UniProt Secondary Accession: | Q2VWA4 |
| UniProt Related Accession: | Q2VWA4 |
| Molecular Weight: | 33,354 Da |
| NCBI Full Name: | SKI family transcriptional corepressor 2 |
| NCBI Synonym Full Names: | SKI family transcriptional corepressor 2 |
| NCBI Official Symbol: | SKOR2 |
| NCBI Official Synonym Symbols: | CORL2; CH18515; FUSSEL18 |
| NCBI Protein Information: | SKI family transcriptional corepressor 2 |
| UniProt Protein Name: | SKI family transcriptional corepressor 2 |
| UniProt Synonym Protein Names: | Functional Smad-suppressing element on chromosome 18; Fussel-18; LBX1 corepressor 1-like protein; Ladybird homeobox corepressor 1-like protein |
| Protein Family: | SKI family transcriptional corepressor |
| UniProt Gene Name: | SKOR2 |
| UniProt Entry Name: | SKOR2_HUMAN |
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