SIRT3 Polyclonal Antibody (CAB21417)
- SKU:
- CAB21417
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | SIRT3 Polyclonal Antibody |
| Product Code: | CAB21417 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, 293T, Hep G2 |
| Cellular Location: | Mitochondrion matrix |
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 299-399 of human SIRT3 (NP_036371.1). |
| Sequence: | PQRFL LHVVD FPMAD LLLIL GTSLE VEPFA SLTEA VRSSV PRLLI NRDLV GPLAW HPRSR DVAQL GDVVH GVESL VELLG WTEEM RDLVQ RETGK LDGPD K |
| Synonyms: | SIR2L3 |
| Calculated MW: | 44kDa |
| Observed MW: | 28kDa |
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