SIRT1 Polyclonal Antibody

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SKU:
CAB21418
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:SIRT1 Polyclonal Antibody
Product Code:CAB21418
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Positive Samples:293T, Jurkat
Cellular Location:Cytoplasm, Mitochondrion, Nucleus, Nucleus, PML body

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SIRT1 (NP_036370.2).
Sequence:TILKD LLPET IPPPE LDDMT LWQIV INILS EPPKR KKRKD INTIE DAVKL LQECK KIIVL TGAGV SVSCG IPDFR SRDGI YARLA VDFPD LPDPQ AMFDI E
Synonyms:SIR2, SIR2L1, SIR2alpha
Calculated MW:82kDa
Observed MW:120KD
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