Name: SIRPB1 Antibody (PACO46202)
SKU: PACO46202
Availability: OutOfStock

Antibody Name:	SIRPB1 Antibody (PACO46202)
Antibody SKU:	PACO46202
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Recombinant Human Signal-regulatory protein beta-1 protein (30-371AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot. All lanes: SIRPB1 antibody at 6µg/ml. Lane 1: A549 whole cell lysate. Lane 2: PC-3 whole cell lysate. Lane 3: A375 whole cell lysate. Lane 4: Mouse heart tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 44, 20 kDa. Observed band size: 44 kDa..
	Immunohistochemistry of paraffin-embedded human colon cancer using PACO46202 at dilution of 1:100.
	Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO46202 at dilution of 1:100.

Background:	Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.
Synonyms:	Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b), SIRPB1

UniProt Protein Function:	SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: protein bindingBiological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
UniProt Code:	O00241
NCBI GenInfo Identifier:	311033545
NCBI Gene ID:	10326
NCBI Accession:	O00241.5
UniProt Secondary Accession:	O00241,Q5TFQ9, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0, A6NLM2 B2R8V0
UniProt Related Accession:	O00241,Q5TFQ8, O00241
Molecular Weight:	43,359 Da
NCBI Full Name:	Signal-regulatory protein beta-1
NCBI Synonym Full Names:	signal regulatory protein beta 1
NCBI Official Symbol:	SIRPB1
NCBI Official Synonym Symbols:	CD172b; SIRP-BETA-1
NCBI Protein Information:	signal-regulatory protein beta-1
UniProt Protein Name:	Signal-regulatory protein beta-1
UniProt Synonym Protein Names:	CD172 antigen-like family member B; CD_antigen: CD172b
Protein Family:	Signal-regulatory protein
UniProt Gene Name:	SIRPB1
UniProt Entry Name:	SIRB1_HUMAN