| UniProt Protein Function: | SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: protein bindingBiological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | O00241 |
| NCBI GenInfo Identifier: | 311033545 |
| NCBI Gene ID: | 10326 |
| NCBI Accession: | O00241.5 |
| UniProt Secondary Accession: | O00241,Q5TFQ9, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0, A6NLM2 B2R8V0 |
| UniProt Related Accession: | O00241,Q5TFQ8, O00241 |
| Molecular Weight: | 43,359 Da |
| NCBI Full Name: | Signal-regulatory protein beta-1 |
| NCBI Synonym Full Names: | signal regulatory protein beta 1 |
| NCBI Official Symbol: | SIRPB1 |
| NCBI Official Synonym Symbols: | CD172b; SIRP-BETA-1 |
| NCBI Protein Information: | signal-regulatory protein beta-1 |
| UniProt Protein Name: | Signal-regulatory protein beta-1 |
| UniProt Synonym Protein Names: | CD172 antigen-like family member B; CD_antigen: CD172b |
| Protein Family: | Signal-regulatory protein |
| UniProt Gene Name: | SIRPB1 |
| UniProt Entry Name: | SIRB1_HUMAN |
