SIGLEC11 Antibody (PACO20462)
- SKU:
- PACO20462
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SIGLEC11 Antibody (PACO20462) |
| Antibody SKU: | PACO20462 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human SIGLEC11 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20462(SIGLEC11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20462(SIGLEC11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the sialic acid, binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid, recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | sialic acid, binding Ig-like lectin 11 |
| UniProt Protein Function: | SIGLEC11: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 19q13.33 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q96RL6 |
| NCBI GenInfo Identifier: | 294862467 |
| NCBI Gene ID: | 114132 |
| NCBI Accession: | Q96RL6.2 |
| UniProt Secondary Accession: | Q96RL6 |
| UniProt Related Accession: | Q96RL6 |
| Molecular Weight: | 65,818 Da |
| NCBI Full Name: | Sialic acid-binding Ig-like lectin 11 |
| NCBI Synonym Full Names: | sialic acid binding Ig like lectin 11 |
| NCBI Official Symbol: | SIGLEC11 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | sialic acid-binding Ig-like lectin 11 |
| UniProt Protein Name: | Sialic acid-binding Ig-like lectin 11 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Sialic acid-binding Ig-like lectin |
| UniProt Gene Name: | SIGLEC11 |
| UniProt Entry Name: | SIG11_HUMAN |
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