Siglec-8 Monoclonal Antibody (CAB21172)
- SKU:
- CAB21172
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- FC
Description
| Product Name: | Siglec-8 Monoclonal Antibody |
| Product Code: | CAB21172 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Flow Cytometry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52425 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, FC, ELISA |
| Key Applications: | Western blotting, Flow Cytometry |
| Recommended Dilution: | WB 1:2000-1:10000, FC 1:50-1:100 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T |
| Cellular Location: | plasma membrane |
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-363 of human Siglec-8 (NP_055257.2). |
| Sequence: | MEGDR QYGDG YLLQV QELVT VQEGL CVHVP CSFSY PQDGW TDSDP VHGYW FRAGD RPYQD APVAT NNPDR EVQAE TQGRF QLLGD IWSND CSLSI RDARK RDKGS YFFRL ERGSM KWSYK SQLNY KTKQL SVFVT ALTHR PDILI LGTLE SGHSR NLTCS VPWAC KQGTP PMISW IGASV SSPGP TTARS SVLTL TPKPQ DHGTS LTCQV TLPGT GVTTT STVRL DVSYP PWNLT MTVFQ GDATA STALG NGSSL SVLEG QSLRL VCAVN SNPPA RLSWT RGSLT LCPSR SSNPG LLELP RVHVR DEGEF TCRAQ NAQGS QHISL SLSLQ NEGTG TSRPV SQVTL AA |
| Synonyms: | SAF2, SIGLEC-8, SIGLEC8L, SIGLEC8 |
| Calculated MW: | 54kDa |
| Observed MW: | 60kDa |
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