SHROOM3 Antibody (PACO46922)
- SKU:
- PACO46922
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SHROOM3 Antibody (PACO46922) |
| Antibody SKU: | PACO46922 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein Shroom3 protein (1309-1571AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO46922 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO46922 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). |
| Synonyms: | Protein Shroom3 (Shroom-related protein) (hShrmL), SHROOM3, KIAA1481 SHRML |
| UniProt Protein Function: | SHRM: a filamentous-actin binding protein. Required for normal neural tube closure and cytoskeletal polarity in developing neuroepithelial cells.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 4q21.1Cellular Component: adherens junction; apical junction complex; apical plasma membrane; cytoskeletonBiological Process: apical protein localization; cell morphogenesis; cellular pigment accumulation; pattern specification process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011] |
| UniProt Code: | Q8TF72 |
| NCBI GenInfo Identifier: | 203098098 |
| NCBI Gene ID: | 57619 |
| NCBI Accession: | NP_065910.3 |
| UniProt Secondary Accession: | Q8TF72,Q5QTQ3, Q6ZRW3, Q96IR9, Q9P247 |
| UniProt Related Accession: | Q8TF72 |
| Molecular Weight: | |
| NCBI Full Name: | protein Shroom3 |
| NCBI Synonym Full Names: | shroom family member 3 |
| NCBI Official Symbol: | SHROOM3 |
| NCBI Official Synonym Symbols: | SHRM; APXL3; ShrmL; MSTP013 |
| NCBI Protein Information: | protein Shroom3 |
| UniProt Protein Name: | Protein Shroom3 |
| UniProt Synonym Protein Names: | Shroom-related protein; hShrmL |
| Protein Family: | Protein |
| UniProt Gene Name: | SHROOM3 |
| UniProt Entry Name: | SHRM3_HUMAN |
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