SHQ1 Antibody (PACO62487)
- SKU:
- PACO62487
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SHQ1 Antibody (PACO62487) |
| Antibody SKU: | PACO62487 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein SHQ1 homolog protein (6-223AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO62487 diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. |
| Synonyms: | Protein SHQ1 homolog, SHQ1 |
| UniProt Protein Function: | SHQ1: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. Belongs to the SHQ1 family.Chromosomal Location of Human Ortholog: 3p13Cellular Component: Cajal body; cytoplasm; nucleolus; nucleoplasmMolecular Function: protein bindingBiological Process: positive regulation of apoptosis; protein-RNA complex assembly |
| UniProt Protein Details: | |
| NCBI Summary: | SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010] |
| UniProt Code: | Q6PI26 |
| NCBI GenInfo Identifier: | 158563966 |
| NCBI Gene ID: | 55164 |
| NCBI Accession: | Q6PI26.2 |
| UniProt Secondary Accession: | Q6PI26,Q6MZJ4, Q7Z748, Q9H7E5, Q9NVS8, B4DL05 |
| UniProt Related Accession: | Q6PI26 |
| Molecular Weight: | 61,548 Da |
| NCBI Full Name: | Protein SHQ1 homolog |
| NCBI Synonym Full Names: | SHQ1, H/ACA ribonucleoprotein assembly factor |
| NCBI Official Symbol: | SHQ1 |
| NCBI Official Synonym Symbols: | Shq1p; GRIM-1 |
| NCBI Protein Information: | protein SHQ1 homolog |
| UniProt Protein Name: | Protein SHQ1 homolog |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protein |
| UniProt Gene Name: | SHQ1 |
| UniProt Entry Name: | SHQ1_HUMAN |
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