SHP2 Monoclonal Antibody
- SKU:
- CAB22429
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IP
Description
| Product Name: | SHP2 Monoclonal Antibody |
| Product Code: | CAB22429 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC0356 |
| Reactivity: | Human |
| Tested Applications: | WB, IP, ELISA |
| Key Applications: | Western blotting, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IP 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, 293T, Jurkat, U-251MG |
| Cellular Location: | Cytoplasm |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 502-593 of human SHP2 (Q06124). |
| Sequence: | SGMVQ TEAQY RFIYM AVQHY IETLQ RRIEE EQKSK RKGHE YTNIK YSLAD QTSGD QSPLP PCTPT PPCAE MREDS ARVYE NVGLM QQQKS FR |
| Synonyms: | CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3 |
| Calculated MW: | 68kDa |
| Observed MW: | 72kDa |
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