SHANK1 Antibody (PACO18890)
- SKU:
- PACO18890
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SHANK1 Antibody (PACO18890) |
| Antibody SKU: | PACO18890 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human SHANK1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO18890(SHANK1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute. |
| Background: | SHANK1 seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Synonyms: | SH3 and multiple ankyrin repeat domains 1 |
| UniProt Protein Function: | SHANK1: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Belongs to the SHANK family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 19q13.3Cellular Component: postsynaptic membrane; neuron projection; membrane; dendrite; cytoplasm; dendritic spine; plasma membrane; excitatory synapse; ionotropic glutamate receptor complex; intracellular; cell junction; N-methyl-D-aspartate selective glutamate receptor complexMolecular Function: somatostatin receptor binding; protein C-terminus binding; ionotropic glutamate receptor binding; identical protein binding; protein binding; protein complex binding; GKAP/Homer scaffold activity; SH3 domain bindingBiological Process: negative regulation of actin filament bundle formation; synapse maturation; olfactory behavior; cytoskeletal anchoring; righting reflex; social behavior; habituation; determination of affect; long-term memory; adult behavior; protein complex assembly; neuromuscular process controlling balance; associative learning |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y566 |
| NCBI GenInfo Identifier: | 120587025 |
| NCBI Gene ID: | 50944 |
| NCBI Accession: | NP_057232.2 |
| UniProt Secondary Accession: | Q9Y566,Q9NYW9, A8MXP5, B7WNY6 |
| UniProt Related Accession: | Q9Y566 |
| Molecular Weight: | 224,959 Da |
| NCBI Full Name: | SH3 and multiple ankyrin repeat domains protein 1 |
| NCBI Synonym Full Names: | SH3 and multiple ankyrin repeat domains 1 |
| NCBI Official Symbol: | SHANK1 |
| NCBI Official Synonym Symbols: | SSTRIP; SPANK-1; synamon |
| NCBI Protein Information: | SH3 and multiple ankyrin repeat domains protein 1; SSTR-interacting protein; somatostatin receptor-interacting protein |
| UniProt Protein Name: | SH3 and multiple ankyrin repeat domains protein 1 |
| UniProt Synonym Protein Names: | Somatostatin receptor-interacting protein; SSTR-interacting protein; SSTRIP |
| Protein Family: | SH3 and multiple ankyrin repeat domains protein |
| UniProt Gene Name: | SHANK1 |
| UniProt Entry Name: | SHAN1_HUMAN |
| Antibodies |
| SHANK1 Antibody (PACO12191) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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