SH3BP5 Antibody (PACO47650)
- SKU:
- PACO47650
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SH3BP5 Antibody (PACO47650) |
| Antibody SKU: | PACO47650 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human SH3 domain-binding protein 5 protein (49-455AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse heart tissue, Mouse brain tissue, Mouse kidney tissue. All lanes: SH3BP5 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 51, 33 kDa. Observed band size: 51 kDa.. |
 | Immunofluorescent analysis of Hela cells using PACO47650 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO47650 at dilution of 1:100. |
| Background: | Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. |
| Synonyms: | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK), SH3BP5, SAB |
| UniProt Protein Function: | SH3BP5: Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Belongs to the SH3BP5 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3p24.3Cellular Component: mitochondrion; cytoplasmMolecular Function: protein binding; protein kinase inhibitor activity; SH3 domain bindingBiological Process: negative regulation of protein kinase activity; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O60239 |
| NCBI GenInfo Identifier: | 124028536 |
| NCBI Gene ID: | 9467 |
| NCBI Accession: | O60239.2 |
| UniProt Secondary Accession: | O60239,Q5JWV9, B3KQW6 |
| UniProt Related Accession: | O60239 |
| Molecular Weight: | 32,202 Da |
| NCBI Full Name: | SH3 domain-binding protein 5 |
| NCBI Synonym Full Names: | SH3-domain binding protein 5 (BTK-associated) |
| NCBI Official Symbol: | SH3BP5 |
| NCBI Official Synonym Symbols: | SAB; SH3BP-5 |
| NCBI Protein Information: | SH3 domain-binding protein 5; SH3 domain-binding protein that preferentially associates with BTK |
| UniProt Protein Name: | SH3 domain-binding protein 5 |
| UniProt Synonym Protein Names: | SH3 domain-binding protein that preferentially associates with BTK |
| Protein Family: | SH3 domain-binding protein |
| UniProt Gene Name: | SH3BP5 |
| UniProt Entry Name: | 3BP5_HUMAN |
| Antibodies |
| SH3BP5 Antibody (PACO12183) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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