SH3BP1 Antibody (PACO59021)
- SKU:
- PACO59021
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SH3BP1 Antibody (PACO59021) |
| Antibody SKU: | PACO59021 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human SH3 domain-binding protein 1 protein (161-266AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59021 diluted at 1:400 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity). |
| Synonyms: | SH3 domain-binding protein 1, SH3BP1 |
| UniProt Protein Function: | SH3BP1: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; Adaptor/scaffold; GAPsChromosomal Location of Human Ortholog: 22q13.1Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y3L3 |
| NCBI GenInfo Identifier: | 51338841 |
| NCBI Gene ID: | 23616 |
| NCBI Accession: | Q9Y3L3.3 |
| UniProt Secondary Accession: | Q9Y3L3,Q5R3N0, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9 |
| UniProt Related Accession: | Q9Y3L3 |
| Molecular Weight: | 50,820 Da |
| NCBI Full Name: | SH3 domain-binding protein 1 |
| NCBI Synonym Full Names: | SH3 domain binding protein 1 |
| NCBI Official Symbol: | SH3BP1 |
| NCBI Official Synonym Symbols: | ARHGAP43 |
| NCBI Protein Information: | SH3 domain-binding protein 1 |
| UniProt Protein Name: | SH3 domain-binding protein 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | SH3 domain-binding protein |
| UniProt Gene Name: | SH3BP1 |
| UniProt Entry Name: | 3BP1_HUMAN |
| Antibodies |
| SH3BP1 Antibody (PACO12181) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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