SFTPC Monoclonal Antibody
- SKU:
- CAB23181
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | SFTPC Monoclonal Antibody |
| Product Code: | CAB23181 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC59447 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:1000-1:5000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Rat lung |
| Cellular Location: | Secreted, extracellular space, surface film |
| Customer Validation: | IF(Homo sapiens) |
This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
| Immunogen: | Recombinant protein of human surfactant protein c/SP-C. |
| Sequence: | MDVGS KEVLM ESPPD YSAAP RGRFG IPCCP VHLKR LLIVV VVVVL IVVVI VGALL MGLHM SQKHT EMVLE MSIGA PEAQQ RLALS EHLVT TATFS IGSTG LVVYD YQQLL IAYKP APGTC CYIMK IAPES IPSLE ALNRK VHNFQ MECSL QAKPA VPTSK LGQAE GRDAG SAPSG GDPAF LGMAV NTLCG EVPLY YI |
| Synonyms: | SP5, SP-C, PSP-C, SFTP2, SMDP2, BRICD6 |
| Calculated MW: | 21kDa |
| Observed MW: | 21-25kDa |
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