SEZ6L Antibody (PACO20451)
- SKU:
- PACO20451
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SEZ6L Antibody (PACO20451) |
| Antibody SKU: | PACO20451 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human SEZ6L |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20451(SEZ6L Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20451(SEZ6L Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | SEZ6L (seizure related 6 homolog-like) is a 1,024 amino acid, single-pass type I membrane protein that localizes to the endoplasmic reticulum. Widely expressed, SEZ6L is a candidate tumor suppressor gene and may contribute to specialized endoplasmic reticulum functions in neurons. SEZ6L contains three CUB domains and five sushi (CCP/SCR) domains, which may be involved in protein-protein interactions and signal transduction. The gene encoding SEZ6L is located on human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. |
| Synonyms: | seizure related 6 homolog (mouse)-like |
| UniProt Protein Function: | SEZ6L: May contribute to specialized endoplasmic reticulum functions in neurons. Belongs to the SEZ6 family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 22q12.1Cellular Component: endoplasmic reticulum membrane; cell soma; integral to membraneBiological Process: synapse maturation; adult locomotory behavior; cerebellar Purkinje cell layer development |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9BYH1 |
| NCBI GenInfo Identifier: | 296179436 |
| NCBI Gene ID: | 23544 |
| NCBI Accession: | NP_001171702.1 |
| UniProt Secondary Accession: | Q9BYH1,O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4 A0AUW7, B0QYG4, B0QYG5 |
| UniProt Related Accession: | Q9BYH1 |
| Molecular Weight: | 111,782 Da |
| NCBI Full Name: | seizure 6-like protein isoform 2 |
| NCBI Synonym Full Names: | seizure related 6 homolog (mouse)-like |
| NCBI Official Symbol: | SEZ6L |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | seizure 6-like protein; seizure related gene 6-like |
| UniProt Protein Name: | Seizure 6-like protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Seizure 6-like protein |
| UniProt Gene Name: | SEZ6L |
| UniProt Entry Name: | SE6L1_HUMAN |
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