SERPINA11 Antibody (PACO03783)
- SKU:
- PACO03783
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SERPINA11 Antibody |
| Antibody SKU: | PACO03783 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human Serpin A11. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SERPINA11; Serpin A11 |
| UniProt Protein Function: | SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: extracellular space; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I |
| UniProt Code: | Q86U17 |
| NCBI GenInfo Identifier: | 122937297 |
| NCBI Gene ID: | 256394 |
| NCBI Accession: | NP_001073920 |
| UniProt Secondary Accession: | Q86U17,Q86U17, |
| UniProt Related Accession: | Q86U17 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | serpin A11 |
| NCBI Synonym Full Names: | serpin family A member 11 |
| NCBI Official Symbol: | SERPINA11 |
| NCBI Protein Information: | serpin A11 |
| UniProt Protein Name: | Plasma protease C1 inhibitor |
| UniProt Synonym Protein Names: | C1 esterase inhibitor; C1-inhibiting factor; Serpin G1 |
| Protein Family: | Plasma protease C1 inhibitor |
| UniProt Gene Name: | SERPING1 |
| UniProt Entry Name: | IC1_HUMAN |
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