SERF1A Antibody (PACO59884)
- SKU:
- PACO59884
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SERF1A Antibody (PACO59884) |
| Antibody SKU: | PACO59884 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Small EDRK-rich factor 1 protein (1-74AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59884 diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | nervous system development |
| Synonyms: | Small EDRK-rich factor 1 (Protein 4F5) (h4F5) (SMA modifier 1), SERF1A; SERF1B, FAM2A SERF1 SMAM1; FAM2B SERF1 SMAM1 |
| UniProt Protein Function: | SERF1: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The duplication region includes both a telomeric and a centromeric copy of this gene. Deletions of this gene, the telomeric copy, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype. The function of this protein is not known; however, it bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 5q13Biological Process: nervous system development |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is the centromeric copy which is identical to the telomeric copy. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. The gene encodes a protein of unknown function which bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75920 |
| NCBI GenInfo Identifier: | 296010886 |
| NCBI Gene ID: | 728492 |
| NCBI Accession: | NP_001171558.1 |
| UniProt Secondary Accession: | O75920,O75919, Q52LK5, B7ZKM2 |
| UniProt Related Accession: | O75920 |
| Molecular Weight: | 7,336 Da |
| NCBI Full Name: | small EDRK-rich factor 1 isoform 1 |
| NCBI Synonym Full Names: | small EDRK-rich factor 1B (centromeric) |
| NCBI Official Symbol: | SERF1B |
| NCBI Official Synonym Symbols: | h4F5; FAM2B; H4F5C |
| NCBI Protein Information: | small EDRK-rich factor 1 |
| UniProt Protein Name: | Small EDRK-rich factor 1 |
| UniProt Synonym Protein Names: | Protein 4F5; h4F5; SMA modifier 1 |
| Protein Family: | |
| UniProt Gene Name: | SERF1A |
| UniProt Entry Name: | SERF1_HUMAN |
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