SENP7 Antibody (PACO56410)
- SKU:
- PACO56410
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SENP7 Antibody (PACO56410) |
| Antibody SKU: | PACO56410 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sentrin-specific protease 7 protein (128-366AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO56410 diluted at 1:500 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. |
| Synonyms: | Sentrin-specific protease 7 (EC 3.4.22) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7), SENP7, KIAA1707 SSP2 SUSP2 |
| UniProt Protein Function: | Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. |
| NCBI Summary: | The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q9BQF6 |
| NCBI GenInfo Identifier: | 300669717 |
| NCBI Gene ID: | 57337 |
| NCBI Accession: | Q9BQF6.4 |
| UniProt Secondary Accession: | Q9BQF6,Q7Z3F4, Q96PS5, Q9C0F6, Q9HBT5, A1L3A5, A8MW39 B7WNW8, |
| UniProt Related Accession: | Q9BQF6 |
| Molecular Weight: | 112,159 Da |
| NCBI Full Name: | Sentrin-specific protease 7 |
| NCBI Synonym Full Names: | SUMO1/sentrin specific peptidase 7 |
| NCBI Official Symbol: | SENP7 |
| NCBI Protein Information: | sentrin-specific protease 7 |
| UniProt Protein Name: | Sentrin-specific protease 7 |
| UniProt Synonym Protein Names: | SUMO-1-specific protease 2; Sentrin/SUMO-specific protease SENP7 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP7 |
| UniProt Entry Name: | SENP7_HUMAN |
| Antibodies | ELISA Kits |
| SENP7 Antibody (PACO01482) | SENP7 Colorimetric Cell-Based ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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system_update_altDatasheetHuman SENP7 Recombinant Protein Sentrin-Specific Protease 7 (SENP7) acts as a SUMO-2/3-specific protease. SENP7 is likely to regulate the metabolism of poly-SUMO-2/3 rat
