SENP5 Antibody (PACO23148)
- SKU:
- PACO23148
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SENP5 Antibody (PACO23148) |
| Antibody SKU: | PACO23148 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from Internal of human SENP5. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COS7 cells, using SENP5 antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SENP5 antibody. |
| Background: | Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. |
| Synonyms: | EC 3.4.22.-; SUMO1/sentrin specific peptidase 5; |
| UniProt Protein Function: | SENP5: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family. |
| UniProt Protein Details: | Protein type:Nucleolus; Protease; EC 3.4.22.68 Chromosomal Location of Human Ortholog: 3q29 Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity Biological Process: protein desumoylation; protein sumoylation |
| NCBI Summary: | The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q96HI0 |
| NCBI GenInfo Identifier: | 296452962 |
| NCBI Gene ID: | 205564 |
| NCBI Accession: | Q96HI0.3 |
| UniProt Secondary Accession: | Q96HI0,Q96SA5, B4DY82, |
| UniProt Related Accession: | Q96HI0 |
| Molecular Weight: | 81,310 Da |
| NCBI Full Name: | Sentrin-specific protease 5 |
| NCBI Synonym Full Names: | SUMO1/sentrin specific peptidase 5 |
| NCBI Official Symbol: | SENP5 |
| NCBI Protein Information: | sentrin-specific protease 5 |
| UniProt Protein Name: | Sentrin-specific protease 5 |
| UniProt Synonym Protein Names: | Sentrin/SUMO-specific protease SENP5 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP5 |
| UniProt Entry Name: | SENP5_HUMAN |
| Antibodies | ELISA Kits |
| SENP5 Antibody (PACO01481) | SENP5 Colorimetric Cell-Based ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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