SENP5 Antibody (PACO01481)
- SKU:
- PACO01481
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- NHP - Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SENP5 Antibody |
| Antibody SKU: | PACO01481 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Monkey |
| Immunogen: | synthesized peptide derived from the C-terminal region of human SENP5. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SENP5; FKSG45; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5 |
| UniProt Protein Function: | SENP5: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family. |
| UniProt Protein Details: | Protein type:Nucleolus; Protease; EC 3.4.22.68 Chromosomal Location of Human Ortholog: 3q29 Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity Biological Process: protein desumoylation; protein sumoylation |
| NCBI Summary: | The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q96HI0 |
| NCBI GenInfo Identifier: | 296452962 |
| NCBI Gene ID: | 205564 |
| NCBI Accession: | Q96HI0.3 |
| UniProt Secondary Accession: | Q96HI0,Q96SA5, B4DY82, |
| UniProt Related Accession: | Q96HI0 |
| Molecular Weight: | 81,310 Da |
| NCBI Full Name: | Sentrin-specific protease 5 |
| NCBI Synonym Full Names: | SUMO1/sentrin specific peptidase 5 |
| NCBI Official Symbol: | SENP5 |
| NCBI Protein Information: | sentrin-specific protease 5 |
| UniProt Protein Name: | Sentrin-specific protease 5 |
| UniProt Synonym Protein Names: | Sentrin/SUMO-specific protease SENP5 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP5 |
| UniProt Entry Name: | SENP5_HUMAN |
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