Semaphorin-4D/CD100 Monoclonal Antibody
- SKU:
- CAB24404
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- FC
Description
| Product Name: | Semaphorin-4D/CD100 Monoclonal Antibody |
| Product Code: | CAB24404 |
| Reactivity: | Human |
| Applications: | Flow Cytometry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC63157 |
| Reactivity: | Human |
| Tested Applications: | FC, ELISA |
| Key Applications: | Flow Cytometry |
| Recommended Dilution: | FC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
Plexin-B1 is related to axon guidance in the central nervous system. The Sema4D function is also widely detected in the immune system and was found to be the first semaphorin expressed on the surface of many types of immune cells. In the immune system, CD72 is a low-affinity receptor for Sema4D, and studies have shown that Sema4D can not only regulate T cell activation, but also participate in the regulation of B cell survival and differentiation. In the immune system, soluble fragments containing extracellular domains produced by proteolytic cleavage can regulate many physiological functions of Sema4D. Sema4D is also associated with tumorigenesis because studies have confirmed that it is overexpressed in various types of solid tumor cells. To some extent, the role of Sema4D in tumorigenesis is related to its ability to cause tumor angiogenesis, cell invasion, and immunosuppression by enhancing bone marrow-derived suppressor cell function.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-734 of human Semaphorin-4D/CD100(NP_006369.3). |
| Sequence: | MAFAP IPRIT WEHRE VHLVQ FHEPD IYNYS ALLLS EDKDT LYIGA REAVF AVNAL NISEK QHEVY WKVSE DKKAK CAEKG KSKQT ECLNY IRVLQ PLSAT SLYVC GTNAF QPACD HLNLT SFKFL GKNED GKGRC PFDPA HSYTS VMVDG ELYSG TSYNF LGSEP IISRN SSHSP LRTEY AIPWL NEPSF VFADV IRKSP DSPDG EDDRV YFFFT EVSVE YEFVF RVLIP RIARV CKGDQ GGLRT LQKKW TSFLK ARLIC SRPDS GLVFN VLRDV FVLRS PGLKV PVFYA LFTPQ LNNVG LSAVC AYNLS TAEEV FSHGK YMQST TVEQS HTKWV RYNGP VPKPR PGACI DSEAR AANYT SSLNL PDKTL QFVKD HPLMD DSVTP IDNRP RLIKK DVNYT QIVVD RTQAL DGTVY DVMFV STDRG ALHKA ISLEH AVHII EETQL FQDFE PVQTL LLSSK KGNRF VYAGS NSGVV QAPLA FCGKH GTCED CVLAR DPYCA WSPPT ATCVA LHQTE SPSRG LIQEM SGDAS VCPDK SKGSY RQHFF KHGGT AELKC SQKSN LARVF WKFQN GVLKA ESPKY GLMGR KNLLI FNLSE GDSGV YQCLS EERVK NKTVF QVVAK HVLEV KVVPK PVVAP TLSVV QTEGS RIATK VLVAS TQGSS PPTPA VQATS SGAIT LPPKP APTGT SCEPK IVINT VPQLH SEKTM YLKSS DNR |
| Synonyms: | SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin-4D |
| Calculated MW: | 82kDa/96kDa |
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