Description
Product Name: | Semaphorin 3A Monoclonal Antibody |
Product Code: | CAB22204 |
Reactivity: | Human, Mouse |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC56474 |
Reactivity: | Human, Mouse |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:2000-1:20000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
Positive Samples: | U-87MG, SH-SY5Y, NIH/3T3 |
Cellular Location: | Secreted |
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 582-771 of human Semaphorin 3A (NP_006071.1). |
Sequence: | ERIIY GVENS STFLE CSPKS QRALV YWQFQ RRNEE RKEEI RVDDH IIRTD QGLLL RSLQQ KDSGN YLCHA VEHGF IQTLL KVTLE VIDTE HLEEL LHKDD DGDGS KTKEM SNSMT PSQKV WYRDF MQLIN HPNLN TMDEF CEQVW KRDRK QRRQR PGHTP GNSNK WKHLQ ENKKG RNRRT HEFER APRSV |
Synonyms: | HH16, SemD, COLL1, SEMA1, SEMAD, SEMAL, coll-1, Hsema-I, SEMAIII, Hsema-III |
Calculated MW: | 89kDa |
Observed MW: | 95kDa |