SEMA6A Antibody (PACO20421)
- SKU:
- PACO20421
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SEMA6A Antibody (PACO20421) |
| Antibody SKU: | PACO20421 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human SEMA6A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20421(SEMA6A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. |
| Synonyms: | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
| UniProt Protein Function: | SEMA6A: a single-pass type I membrane protein of the semaphorin family that can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Active as a homodimer or oligomer. Interacts with EVL. Two isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 5q23.1Cellular Component: integral to plasma membraneMolecular Function: chemorepellent activity; protein binding; semaphorin receptor bindingBiological Process: negative regulation of axon extension involved in axon guidance; neural crest cell migration |
| UniProt Protein Details: | |
| NCBI Summary: | The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011] |
| UniProt Code: | Q9H2E6 |
| NCBI GenInfo Identifier: | 296452903 |
| NCBI Gene ID: | 57556 |
| NCBI Accession: | Q9H2E6.2 |
| UniProt Secondary Accession: | Q9H2E6,Q9P2H9 |
| UniProt Related Accession: | Q9H2E6 |
| Molecular Weight: | 116,336 Da |
| NCBI Full Name: | Semaphorin-6A |
| NCBI Synonym Full Names: | semaphorin 6A |
| NCBI Official Symbol: | SEMA6A |
| NCBI Official Synonym Symbols: | VIA; SEMA; HT018; SEMAQ; SEMA6A1 |
| NCBI Protein Information: | semaphorin-6A |
| UniProt Protein Name: | Semaphorin-6A |
| UniProt Synonym Protein Names: | Semaphorin VIA; Sema VIA; Semaphorin-6A-1; SEMA6A-1 |
| Protein Family: | Semaphorin |
| UniProt Gene Name: | SEMA6A |
| UniProt Entry Name: | SEM6A_HUMAN |
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