SDHB Polyclonal Antibody
- SKU:
- CAB22020
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | SDHB Polyclonal Antibody |
| Product Code: | CAB22020 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:100-1:500, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | K-562, Mouse heart, Mouse kidney, Rat heart, Rat kidney |
| Cellular Location: | mitochondrial inner membrane, mitochondrial membrane, mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), mitochondrion, nucleoplasm, plasma membrane |
This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. This enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in this gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorigenesis. Mutations in this gene are also implicated in nuclear type 4 mitochondrial complex II deficiency.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human SDHB (NP_002991.2). |
| Sequence: | AQTAA ATAPR IKKFA IYRWD PDKAG DKPHM QTYEV DLNKC GPMVL DALIK IKNEV DSTLT FRRSC REGIC GSCAM NINGG NTLAC TRRID TNLNK VSKIY PLPHM YVIKD LVPDL SNFYA QYKSI EPYLK KKDES QEGKQ QYLQS IEERE KLDGL YECIL CACCS TSCPS YWWNG DKYLG PAVLM QAYRW MIDSR DDFTE ERLAK LQDPF SLYRC HTIMN CTRTC PKGLN PGKAI AEIKK MMATY KEKKA SV |
| Synonyms: | IP, SDH, CWS2, PGL4, SDH1, SDH2, SDHIP, MC2DN4 |
| Calculated MW: | 32kDa |
| Observed MW: | 32kDa |
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