SDHB Monoclonal Antibody
- SKU:
- CAB23832
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | SDHB Monoclonal Antibody |
| Product Code: | CAB23832 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC61606 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:2000-1:4000, IHC-P 1:50-1:200, IF 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | SK-MEL-28, K-562, 293T, Mouse heart, Rat heart |
| Cellular Location: | Matrix side, Mitochondrion inner membrane, Peripheral membrane protein |
| Customer Validation: | (Kidney, liver) |
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human SDHB (P21912). |
| Sequence: | AQTAA ATAPR IKKFA IYRWD PDKAG DKPHM QTYEV DLNKC GPMVL DALIK IKNEV DSTLT FRRSC REGIC GSCAM NINGG NTLAC TRRID TNLNK VSKIY PLPHM YVIKD LVPDL SNFYA QYKSI EPYLK KKDES QEGKQ QYLQS IEERE KLDGL YECIL CACCS TSCPS YWWNG DKYLG PAVLM QAYRW MIDSR DDFTE ERLAK LQDPF SLYRC HTIMN CTRTC PKGLN PGKAI AEIKK MMATY KEKKA SV |
| Synonyms: | SDHB, CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase complex iron sulfur subunit B |
| Calculated MW: | 31kDa |
| Observed MW: | 32kDa |
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