SCN4B Antibody (PACO63815)
- SKU:
- PACO63815
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SCN4B Antibody (PACO63815) |
| Antibody SKU: | PACO63815 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sodium channel subunit beta-4 protein (31-162AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of HepG2 cells with PACO63815 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain α sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. |
| Synonyms: | Sodium channel subunit beta-4, SCN4B |
| UniProt Protein Function: | SCN4B: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11q23.3Cellular Component: intrinsic to plasma membrane; voltage-gated sodium channel complexMolecular Function: sodium channel regulator activity; voltage-gated sodium channel activityBiological Process: cardiac muscle contraction; sodium ion transportDisease: Long Qt Syndrome 10 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009] |
| UniProt Code: | Q8IWT1 |
| NCBI GenInfo Identifier: | 57012701 |
| NCBI Gene ID: | 6330 |
| NCBI Accession: | Q8IWT1.1 |
| UniProt Secondary Accession: | Q8IWT1,Q6PIG5, E9PPT5 |
| UniProt Related Accession: | Q8IWT1 |
| Molecular Weight: | 9,876 Da |
| NCBI Full Name: | Sodium channel subunit beta-4 |
| NCBI Synonym Full Names: | sodium voltage-gated channel beta subunit 4 |
| NCBI Official Symbol: | SCN4B |
| NCBI Official Synonym Symbols: | LQT10; ATFB17; Navbeta4 |
| NCBI Protein Information: | sodium channel subunit beta-4 |
| UniProt Protein Name: | Sodium channel subunit beta-4 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Sodium channel |
| UniProt Gene Name: | SCN4B |
| UniProt Entry Name: | SCN4B_HUMAN |
| Antibodies |
| SCN4B Antibody (PACO01477) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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