Antibody Name:	SCN4A Antibody (PACO22616)
Antibody SKU:	PACO22616
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human SCN4A.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from K562 cells, using SCN4A antibody.

Background:

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.

Synonyms:

Sodium channel protein type 4 subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4; Sodium channel protein skeletal muscle subunit alpha; SkM1

UniProt Protein Function:	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
NCBI Summary:	Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008]
UniProt Code:	P35499
NCBI GenInfo Identifier:	93587342
NCBI Gene ID:	6329
NCBI Accession:	NP_000325.4
UniProt Secondary Accession:	P35499,Q15478, Q16447, Q7Z6B1,
UniProt Related Accession:	P35499
Molecular Weight:	208 kDa
NCBI Full Name:	sodium channel protein type 4 subunit alpha
NCBI Synonym Full Names:	sodium voltage-gated channel alpha subunit 4
NCBI Official Symbol:	SCN4A
NCBI Official Synonym Symbols:	HYPP; SkM1; CMS16; HYKPP; NAC1A; HOKPP2; Nav1.4; Na(V)1.4
NCBI Protein Information:	sodium channel protein type 4 subunit alpha
UniProt Protein Name:	Sodium channel protein type 4 subunit alpha
UniProt Synonym Protein Names:	SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4
Protein Family:	Sodium channel protein
UniProt Gene Name:	SCN4A