Antibody Name:	SCN11A Antibody (PACO23524)
Antibody SKU:	PACO23524
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human sodium channel, voltage-gated, type XI, alpha subunit

Form:	Liquid
Storage Buffer:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Purification Method:	Antigen Affinity Purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/40.
	Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/40.

Background:

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.

Synonyms:

NaN; SNS-2; NAV1.9; SCN12A

UniProt Protein Function:	Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Ref.1 Ref.3
UniProt Protein Details:	Subunit structure: The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B. Subcellular location: Membrane; Multi-pass membrane protein By similarity. Tissue specificity: Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. Ref.2 Ref.5 Domain: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. Post-translational modification: Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity. Sequence similarities: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily. [View classification]
NCBI Summary:	This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UI33
NCBI GenInfo Identifier:	19924165
NCBI Gene ID:	6098
NCBI Accession:	NP_002935.2
UniProt Secondary Accession:	Q9UI33,Q15368, Q5TDB5,
UniProt Related Accession:	P08922
Molecular Weight:	263,915 Da
NCBI Full Name:	proto-oncogene tyrosine-protein kinase ROS
NCBI Synonym Full Names:	ROS proto-oncogene 1, receptor tyrosine kinase
NCBI Official Symbol:	ROS1
NCBI Official Synonym Symbols:	ROS; MCF3; c-ros-1
NCBI Protein Information:	proto-oncogene tyrosine-protein kinase ROS
UniProt Protein Name:	Sodium channel protein type 11 subunit alpha
UniProt Synonym Protein Names:	Peripheral nerve sodium channel 5; PN5; Sensory neuron sodium channel 2; Sodium channel protein type XI subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.9; hNaN
Protein Family:	Protein
UniProt Gene Name:	SCN11A
UniProt Entry Name:	SCNBA_HUMAN