SCN11A Antibody (PACO18879)
- SKU:
- PACO18879
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SCN11A Antibody (PACO18879) |
| Antibody SKU: | PACO18879 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human SCN11A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18879(SCN11A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18879(SCN11A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. α subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary β subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of α subunits underlie a number of disorders. Each α subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers. |
| Synonyms: | sodium channel, voltage-gated, type XI, α subunit |
| UniProt Protein Function: | Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Ref.1 Ref.3 |
| UniProt Protein Details: | Subunit structure: The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B. Subcellular location: Membrane; Multi-pass membrane protein By similarity. Tissue specificity: Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. Ref.2 Ref.5 Domain: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. Post-translational modification: Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity. Sequence similarities: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily. [View classification] |
| NCBI Summary: | This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UI33 |
| NCBI GenInfo Identifier: | 19924165 |
| NCBI Gene ID: | 6098 |
| NCBI Accession: | NP_002935.2 |
| UniProt Secondary Accession: | Q9UI33,Q15368, Q5TDB5, |
| UniProt Related Accession: | P08922 |
| Molecular Weight: | 263,915 Da |
| NCBI Full Name: | proto-oncogene tyrosine-protein kinase ROS |
| NCBI Synonym Full Names: | ROS proto-oncogene 1, receptor tyrosine kinase |
| NCBI Official Symbol: | ROS1 |
| NCBI Official Synonym Symbols: | ROS; MCF3; c-ros-1 |
| NCBI Protein Information: | proto-oncogene tyrosine-protein kinase ROS |
| UniProt Protein Name: | Sodium channel protein type 11 subunit alpha |
| UniProt Synonym Protein Names: | Peripheral nerve sodium channel 5; PN5; Sensory neuron sodium channel 2; Sodium channel protein type XI subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.9; hNaN |
| Protein Family: | Protein |
| UniProt Gene Name: | SCN11A |
| UniProt Entry Name: | SCNBA_HUMAN |
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