Antibody Name:	SCN11A Antibody (PACO18878)
Antibody SKU:	PACO18878
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human SCN11A

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18878(SCN11A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18878(SCN11A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. α subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary β subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of α subunits underlie a number of disorders. Each α subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.

Synonyms:

sodium channel, voltage-gated, type XI, α subunit

UniProt Protein Function:	Function: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Ref.1 Ref.3
UniProt Protein Details:	Subunit structure: The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B. Subcellular location: Membrane; Multi-pass membrane protein By similarity. Tissue specificity: Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. Ref.2 Ref.5 Domain: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. Post-translational modification: Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity. Sequence similarities: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily. [View classification]
NCBI Summary:	This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UI33
NCBI GenInfo Identifier:	19924165
NCBI Gene ID:	6098
NCBI Accession:	NP_002935.2
UniProt Secondary Accession:	Q9UI33,Q15368, Q5TDB5,
UniProt Related Accession:	P08922
Molecular Weight:	263,915 Da
NCBI Full Name:	proto-oncogene tyrosine-protein kinase ROS
NCBI Synonym Full Names:	ROS proto-oncogene 1, receptor tyrosine kinase
NCBI Official Symbol:	ROS1
NCBI Official Synonym Symbols:	ROS; MCF3; c-ros-1
NCBI Protein Information:	proto-oncogene tyrosine-protein kinase ROS
UniProt Protein Name:	Sodium channel protein type 11 subunit alpha
UniProt Synonym Protein Names:	Peripheral nerve sodium channel 5; PN5; Sensory neuron sodium channel 2; Sodium channel protein type XI subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.9; hNaN
Protein Family:	Protein
UniProt Gene Name:	SCN11A
UniProt Entry Name:	SCNBA_HUMAN