scn Antibody (PACO40226)
- SKU:
- PACO40226
- Product Type:
- Antibody
- Reactivity:
- Bacteria - Staphylococcus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | scn Antibody (PACO40226) |
| Antibody SKU: | PACO40226 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Staphylococcus aureus |
| Immunogen: | Recombinant Staphylococcus aureus Staphylococcal complement inhibitor protein (32-116AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses. |
| Synonyms: | Staphylococcal complement inhibitor (SCIN), scn |
| UniProt Protein Function: | Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q99SU9 |
| NCBI GenInfo Identifier: | 446624916 |
| NCBI Gene ID: | |
| NCBI Accession: | WP_000702262.1 |
| UniProt Secondary Accession: | Q99SU9 |
| UniProt Related Accession: | Q99SU9 |
| Molecular Weight: | 12.3 kDa |
| NCBI Full Name: | MULTISPECIES: hypothetical protein |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Staphylococcal complement inhibitor |
| UniProt Synonym Protein Names: | |
| Protein Family: | Staphylococcal complement inhibitor |
| UniProt Gene Name: | scn |
| UniProt Entry Name: | SCIN_STAAN |
