Description
Antibody Name: | SCIMP Antibody (PACO60156) |
Antibody SKU: | PACO60156 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human SLP adapter and CSK-interacting membrane protein (59-145AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO60156 diluted at 1:500 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
Immunofluorescence staining of Hela cells with PACO60156 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. |
Synonyms: | SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein), SCIMP, C17orf87 |
UniProt Protein Function: | UNQ5783: Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 17p13.2Cellular Component: immunological synapse; integral to membrane; membraneMolecular Function: protein bindingBiological Process: meiosis I |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012] |
UniProt Code: | Q6UWF3 |
NCBI GenInfo Identifier: | 427197601 |
NCBI Gene ID: | 388325 |
NCBI Accession: | NP_001258771.1 |
UniProt Secondary Accession: | Q6UWF3,Q96MD0, A6XGL4, B4DLK1 |
UniProt Related Accession: | Q6UWF3 |
Molecular Weight: | 15,693 Da |
NCBI Full Name: | SLP adapter and CSK-interacting membrane protein isoform 2 |
NCBI Synonym Full Names: | SLP adaptor and CSK interacting membrane protein |
NCBI Official Symbol: | SCIMP |
NCBI Official Synonym Symbols: | UNQ5783; C17orf87 |
NCBI Protein Information: | SLP adapter and CSK-interacting membrane protein |
UniProt Protein Name: | SLP adapter and CSK-interacting membrane protein |
UniProt Synonym Protein Names: | SLP65/SLP76, Csk-interacting membrane protein |
Protein Family: | SLP adapter and CSK-interacting membrane protein |
UniProt Gene Name: | SCIMP |
UniProt Entry Name: | SCIMP_HUMAN |