SCGB1D2 Antibody (PACO19941)
- SKU:
- PACO19941
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SCGB1D2 Antibody (PACO19941) |
| Antibody SKU: | PACO19941 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human SCGB1D2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19941(SCGB1D2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19941(SCGB1D2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. |
| Synonyms: | secretoglobin, family 1D, member 2 |
| UniProt Protein Function: | SCGB1D2: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones. Belongs to the secretoglobin family. Lipophilin subfamily.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 11q13Cellular Component: extracellular space |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95969 |
| NCBI GenInfo Identifier: | 6831581 |
| NCBI Gene ID: | 10647 |
| NCBI Accession: | O95969.1 |
| UniProt Secondary Accession: | O95969,Q2M3N9 |
| UniProt Related Accession: | O95969 |
| Molecular Weight: | 9,925 Da |
| NCBI Full Name: | Secretoglobin family 1D member 2 |
| NCBI Synonym Full Names: | secretoglobin family 1D member 2 |
| NCBI Official Symbol: | SCGB1D2 |
| NCBI Official Synonym Symbols: | LIPB; LPHB; LPNB |
| NCBI Protein Information: | secretoglobin family 1D member 2 |
| UniProt Protein Name: | Secretoglobin family 1D member 2 |
| UniProt Synonym Protein Names: | Lipophilin-B |
| Protein Family: | Secretoglobin family |
| UniProt Gene Name: | SCGB1D2 |
| UniProt Entry Name: | SG1D2_HUMAN |
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