SCARF2 Antibody (PACO05692)
- SKU:
- PACO05692
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SCARF2 Antibody (PACO05692) |
| Antibody SKU: | PACO05692 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:40000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the Internal region of human SREC-II. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SCARF2; SREC2; SREPCR; Scavenger receptor class F member 2; SRECRP-1; Scavenger receptor expressed by endothelial cells 2 protein; SREC-II |
| UniProt Protein Function: | SREC-II: Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Defects in SCARF2 are the cause of Van den Ende-Gupta syndrome (VDEGS). A syndrome characterized by craniofacial and skeletal abnormalities that include blepharophimosis, a flat and wide nasal bridge, narrow and beaked nose, hypoplastic maxilla with or without cleft palate and everted lower lip, prominent ears, down-slanting eyes, arachnodactyly, and camptodactyly. Patients present congenital joint contractures that improve without intervention, and normal growth and development. Intelligence is normal. Rarely, enlarged cerebella can be present. Some patients experience respiratory problems due to laryngeal abnormalities. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 22q11.21Cellular Component: focal adhesion; integral to membraneMolecular Function: protein binding; scavenger receptor activityBiological Process: heterophilic cell adhesion; receptor-mediated endocytosisDisease: Van Den Ende-gupta Syndrome |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96GP6 |
| NCBI GenInfo Identifier: | 604723370 |
| NCBI Gene ID: | 91179 |
| NCBI Accession: | NP_699165.3 |
| UniProt Secondary Accession: | Q96GP6,Q58A83, Q8IXF3, Q9BW74, E5RFB8 |
| UniProt Related Accession: | Q96GP6 |
| Molecular Weight: | 92,479 Da |
| NCBI Full Name: | scavenger receptor class F member 2 isoform 1 |
| NCBI Synonym Full Names: | scavenger receptor class F, member 2 |
| NCBI Official Symbol: | SCARF2 |
| NCBI Official Synonym Symbols: | NSR1; SREC2; VDEGS; SREC-II; SRECRP-1 |
| NCBI Protein Information: | scavenger receptor class F member 2; scavenger receptor expressed by endothelial cells 2 protein |
| UniProt Protein Name: | Scavenger receptor class F member 2 |
| UniProt Synonym Protein Names: | SRECRP-1; Scavenger receptor expressed by endothelial cells 2 protein; SREC-II |
| Protein Family: | Scavenger receptor |
| UniProt Gene Name: | SCARF2 |
| UniProt Entry Name: | SREC2_HUMAN |
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