SCAMP5 Antibody (PACO39966)
- SKU:
- PACO39966
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SCAMP5 Antibody (PACO39966) |
| Antibody SKU: | PACO39966 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Secretory carrier-associated membrane protein 5 protein (170-235AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39966 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO39966 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. |
| Synonyms: | Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) (hSCAMP5), SCAMP5 |
| UniProt Protein Function: | SCAMP5: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. Belongs to the SCAMP family. SCAMP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 15q24.2Cellular Component: cell junction; Golgi membrane; integral to membrane; plasma membrane; recycling endosome membrane; SNARE complex; synaptic vesicle membrane; trans-Golgi network membraneMolecular Function: protein bindingBiological Process: exocytosis; negative regulation of endocytosis; positive regulation of calcium ion-dependent exocytosis; positive regulation of cytokine secretion; protein transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8TAC9 |
| NCBI GenInfo Identifier: | 296010971 |
| NCBI Gene ID: | 192683 |
| NCBI Accession: | NP_001171582.1 |
| UniProt Secondary Accession: | Q8TAC9,Q8N3M4, B3KPJ7, B7Z762, D3DW71 |
| UniProt Related Accession: | Q8TAC9 |
| Molecular Weight: | 17,932 Da |
| NCBI Full Name: | secretory carrier-associated membrane protein 5 |
| NCBI Synonym Full Names: | secretory carrier membrane protein 5 |
| NCBI Official Symbol: | SCAMP5 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | secretory carrier-associated membrane protein 5 |
| UniProt Protein Name: | Secretory carrier-associated membrane protein 5 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Secretory carrier-associated membrane protein |
| UniProt Gene Name: | SCAMP5 |
| UniProt Entry Name: | SCAM5_HUMAN |
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