SBNO2 Antibody (PACO48186)
- SKU:
- PACO48186
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SBNO2 Antibody (PACO48186) |
| Antibody SKU: | PACO48186 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein strawberry notch homolog 2 protein (6-146AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of HepG2 cells using PACO48186 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the proinflammatory cascade. |
| Synonyms: | Protein strawberry notch homolog 2, SBNO2, KIAA0963 |
| UniProt Protein Function: | SBNO2: Seems to have transcriptional repression activity in macrophages. Belongs to the SBNO family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 19p13.3Biological Process: transcription, DNA-dependent; regulation of inflammatory response; macrophage activation during immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; bone mineralization |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y2G9 |
| NCBI GenInfo Identifier: | 154355004 |
| NCBI Gene ID: | 22904 |
| NCBI Accession: | NP_001093592.1 |
| UniProt Secondary Accession: | Q9Y2G9,O75257, Q3KQX0, Q8TEM0, A8K8P2, B3KWJ1 |
| UniProt Related Accession: | Q9Y2G9 |
| Molecular Weight: | 144,166 Da |
| NCBI Full Name: | protein strawberry notch homolog 2 isoform 2 |
| NCBI Synonym Full Names: | strawberry notch homolog 2 (Drosophila) |
| NCBI Official Symbol: | SBNO2 |
| NCBI Official Synonym Symbols: | SNO; STNO; KIAA0963 |
| NCBI Protein Information: | protein strawberry notch homolog 2 |
| UniProt Protein Name: | Protein strawberry notch homolog 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protein strawberry notch |
| UniProt Gene Name: | SBNO2 |
| UniProt Entry Name: | SBNO2_HUMAN |
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