SARS Spike Polyclonal (CPAB0706)

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SKU:
CPAB0706
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Virus
Applications:
WB
Applications:
IF

Description

system_update_alt Datasheet
Product Name:SARS Spike Polyclonal
Product Sku:CPAB0706
Size:5μg
Host Species:
Immunogen:The antibody was developed by immunizing rabbits with synthetic peptides corresponding to amino acids 1124-114 of the putative SARS Spike glycoprotein (Genbank accession noNP_828851.1).
Clone:
Reactivity:Viral
Applications:Western Blot, Immunofluorescence
Purification Method:
Isotype:
Background:SARS Coronavirus is an enveloped virus containing three outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein plays an important role in virus infection cycle and is the primary target of neutralizing antibodies. It has recently been shown that SARS (severe acute respiratory syndrome) is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness, such as the common cold, in humans. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The glycosilated spike protein (as well as the nucleocapsid protein) can be detected in infected cell culture supernatants with antisera from SARS patients.
Synonyms:
Storage Buffer:
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