SARS Nucleocapsid Polyclonal (CPAB0710)

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SKU:
CPAB0710
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Virus
Applications:
WB
Applications:
IF
Applications:
IHC

Description

system_update_alt Datasheet
Product Name:SARS Nucleocapsid Polyclonal
Product Sku:CPAB0710
Size:5μg
Host Species:
Immunogen:The antibody was developed by immunizing rabbits with synthetic peptides corresponding to amino a.a399-411 of putative SARS nucleocapsid (Genbank accession noNP_828858.1).
Clone:
Reactivity:Viral
Applications:Western Blot, Immunofluorescence, Immunohistochemistry
Purification Method:
Isotype:
Background:SARS Coronavirus is an enveloped virus containing three outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein plays an important role in virus infection cycle and is the primary target of neutralizing antibodies. It has recently been shown that SARS is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness in humans, such as the common cold. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The most prominent protein in the culture supernatants infected with SARS virus is a 46 kDa nucleocapsid protein. This suggests that the nucleocapsid protein is a major immunogen that may be useful for early diagnostics.
Synonyms:
Storage Buffer:
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