SARS Nucleocapsid HRP Monoclonal Antibody [PT3851] (CPAB0423)

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SKU:
CPAB0423
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Virus
Clone:
PT3851
Applications:
ELISA

Description

system_update_alt Datasheet
Product Name:SARS Nucleocapsid HRP Antibody
Product Sku:CPAB0423
Size:100μg
Host Species:
Immunogen:Recombinant protein fragment 1-49 a.aof the SARS nucleoprotein.
Clone:PT3851
Reactivity:Viral
Applications:ELISA
Purification Method:Protein A affinity purified.
Isotype:
Background:SARS Coronavirus is an enveloped virus containing three outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein plays an important role in virus infection cycle and is the primary target of neutralizing antibodies.It has recently been shown that SARS is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness in humans, such as the common cold. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The most prominent protein in the culture supernatants infected with SARS virus is a 46 kDa nucleocapsid protein. This suggests that the nucleocapsid protein is a major immunogen that may be useful for early diagnostics.
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