SARS-CoV-2 NSP3 Recombinant Protein

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SKU:
RPES7051
Product Type:
Recombinant Protein
Species:
Virus

Description

Product Name:SARS-CoV-2 NSP3 Recombinant Protein
Product Code:RPES7051
Size:50µg
Species:SARS-CoV-2
Expression Host:E.coli
Synonyms:nsp3,PL-PRO,Papain-like proteinase,X domain(Macro domain)
Mol Mass:22.03kDa
Tag:N-His
Purity:> 90 % as determined by reducing SDS-PAGE.
Endotoxin Level:Please contact us for more information.
Bio Activity:Testing in progress
Sequence:Glu1024-Gln1198
Accession:QHD43415.1
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyopilized from PBS pH7. 4,0.02%NLS, 1mM EDTA, 4%trehalose,1% mannitol. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
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