SARAF Antibody (PACO39802)
- SKU:
- PACO39802
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SARAF Antibody (PACO39802) |
| Antibody SKU: | PACO39802 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Store-operated calcium entry-associated regulatory factor protein (195-339AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. |
| Synonyms: | Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66), SARAF, TMEM66 XTP3 |
| UniProt Protein Function: | TMEM66: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. Belongs to the SARAF family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 8p12Cellular Component: integral to endoplasmic reticulum membraneMolecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96BY9 |
| NCBI GenInfo Identifier: | 74731293 |
| NCBI Gene ID: | 51669 |
| NCBI Accession: | Q96BY9.1 |
| UniProt Secondary Accession: | Q96BY9,Q53HE8, Q9UNZ3, Q9Y683, B3KQQ4, B7Z9J1, D3DSU7 H9MHJ8, H9MHJ9 |
| UniProt Related Accession: | Q96BY9 |
| Molecular Weight: | 17,876 Da |
| NCBI Full Name: | Store-operated calcium entry-associated regulatory factor |
| NCBI Synonym Full Names: | store-operated calcium entry associated regulatory factor |
| NCBI Official Symbol: | SARAF |
| NCBI Official Synonym Symbols: | XTP3; FOAP-7; TMEM66; HSPC035 |
| NCBI Protein Information: | store-operated calcium entry-associated regulatory factor |
| UniProt Protein Name: | Store-operated calcium entry-associated regulatory factor |
| UniProt Synonym Protein Names: | HBV X-transactivated gene 3 protein; HBV XAg-transactivated protein 3; Protein FOAP-7; Transmembrane protein 66 |
| Protein Family: | Store-operated calcium entry-associated regulatory factor |
| UniProt Gene Name: | SARAF |
| UniProt Entry Name: | SARAF_HUMAN |
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