SAMSN1 Antibody (PACO41974)
- SKU:
- PACO41974
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SAMSN1 Antibody (PACO41974) |
| Antibody SKU: | PACO41974 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human SAM domain-containing protein SAMSN-1 protein (1-373AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO41974 at dilution of 1:100. |
| Background: | Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). |
| Synonyms: | SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein), SAMSN1, HACS1 |
| UniProt Protein Function: | SAMSN1: an adaptor and scaffold protein containing an SH3 and a SAM (sterile alpha motif) domain. Its expression is induced by B cell activation signals. Two alternatively spliced isoforms have been described.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 21q11Cellular Component: ruffle; cytosol; nucleusMolecular Function: phosphotyrosine bindingBiological Process: negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of adaptive immune response; negative regulation of B cell activation |
| UniProt Protein Details: | |
| NCBI Summary: | SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NSI8 |
| NCBI GenInfo Identifier: | 48762709 |
| NCBI Gene ID: | 64092 |
| NCBI Accession: | NP_071419.3 |
| UniProt Secondary Accession: | Q9NSI8,Q8NFF7, Q9C041, B3KWJ3, F8WAA1 |
| UniProt Related Accession: | Q9NSI8 |
| Molecular Weight: | 49,627 Da |
| NCBI Full Name: | SAM domain-containing protein SAMSN-1 isoform 1 |
| NCBI Synonym Full Names: | SAM domain, SH3 domain and nuclear localization signals 1 |
| NCBI Official Symbol: | SAMSN1 |
| NCBI Official Synonym Symbols: | SLy2; HACS1; NASH1; SASH2; SH3D6B |
| NCBI Protein Information: | SAM domain-containing protein SAMSN-1 |
| UniProt Protein Name: | SAM domain-containing protein SAMSN-1 |
| UniProt Synonym Protein Names: | Hematopoietic adaptor containing SH3 and SAM domains 1; Nash1; SAM domain, SH3 domain and nuclear localization signals protein 1; SH3-SAM adaptor protein |
| Protein Family: | SAM domain-containing protein |
| UniProt Gene Name: | SAMSN1 |
| UniProt Entry Name: | SAMN1_HUMAN |
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