Samhd1 Antibody (PACO29744)
- SKU:
- PACO29744
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Samhd1 Antibody (PACO29744) |
| Antibody SKU: | PACO29744 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 protein (426-657AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Samhd1 antibody at 2µg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 76, 75 kDa Observed band size: 76 kDa . |
| Background: | Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-α signaling (By similarity). |
| Synonyms: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Interferon-gamma-inducible protein Mg11) (SAM domain and HD domain-containing protein 1), Samhd1, Mg11 |
| UniProt Protein Function: | SAMHD1: a protein induced by interferon gamma.Protein type: EC 3.1.4.-Chromosomal Location of Human Ortholog: 2|2 H1Cellular Component: nucleoplasm; nucleus; plasma membraneMolecular Function: dGTP binding; dGTPase activity; nucleic acid binding; ribonuclease activity; RNA binding; triphosphoric monoester hydrolase activity; zinc ion bindingBiological Process: dATP catabolic process; defense response to virus; dGTP catabolic process; protein homotetramerization; regulation of innate immune response |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q60710 |
| NCBI GenInfo Identifier: | 213418079 |
| NCBI Gene ID: | 56045 |
| NCBI Accession: | NP_001132992.1 |
| UniProt Secondary Accession: | Q60710,Q3U5X2, Q543A4, Q91VK8 |
| UniProt Related Accession: | Q60710 |
| Molecular Weight: | 30.7kD |
| NCBI Full Name: | deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 2 |
| NCBI Synonym Full Names: | SAM domain and HD domain, 1 |
| NCBI Official Symbol: | Samhd1 |
| NCBI Official Synonym Symbols: | Mg11; E330031J07Rik |
| NCBI Protein Information: | deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
| UniProt Protein Name: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
| UniProt Synonym Protein Names: | Interferon-gamma-inducible protein Mg11; SAM domain and HD domain-containing protein 1 |
| Protein Family: | |
| UniProt Gene Name: | Samhd1 |
| UniProt Entry Name: |
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