SAMD8 Antibody (PACO50794)
- SKU:
- PACO50794
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SAMD8 Antibody (PACO50794) |
| Antibody SKU: | PACO50794 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sphingomyelin synthase-related protein 1 protein (1-152AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lymph node tissue using PACO50794 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO50794 at dilution of 1:100. |
| Background: | Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. |
| Synonyms: | Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Sterile α motif domain-containing protein 8) (SAM domain-containing protein 8), SAMD8 |
| UniProt Protein Function: | SAMD8: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. Belongs to the sphingomyelin synthase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Cell surface; Membrane protein, multi-passChromosomal Location of Human Ortholog: 10q22.2Cellular Component: integral to membrane; integral to endoplasmic reticulum membraneMolecular Function: transferase activityBiological Process: ceramide biosynthetic process; sphingomyelin biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96LT4 |
| NCBI GenInfo Identifier: | 292658773 |
| NCBI Gene ID: | 142891 |
| NCBI Accession: | NP_001167627.1 |
| UniProt Secondary Accession: | Q96LT4,Q5JSC5, Q5JSC8, Q66K52 |
| UniProt Related Accession: | Q96LT4 |
| Molecular Weight: | 37,609 Da |
| NCBI Full Name: | sphingomyelin synthase-related protein 1 isoform 1 |
| NCBI Synonym Full Names: | sterile alpha motif domain containing 8 |
| NCBI Official Symbol: | SAMD8 |
| NCBI Official Synonym Symbols: | SMSr; HEL-177 |
| NCBI Protein Information: | sphingomyelin synthase-related protein 1; CPE synthase; epididymis luminal protein 177; sphingomyelin synthase related; SAM domain-containing protein 8; ceramide phosphoethanolamine synthase; sterile alpha motif domain-containing protein 8 |
| UniProt Protein Name: | Sphingomyelin synthase-related protein 1 |
| UniProt Synonym Protein Names: | Ceramide phosphoethanolamine synthase; CPE synthase; Sterile alpha motif domain-containing protein 8; SAM domain-containing protein 8 |
| Protein Family: | Sphingomyelin phosphodiesterase |
| UniProt Gene Name: | SAMD8 |
| UniProt Entry Name: | SAMD8_HUMAN |
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