ruvA Antibody (PACO34778)
- SKU:
- PACO34778
- Product Type:
- Antibody
- Reactivity:
- Bacteria - Escherichia coli
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ruvA Antibody (PACO34778) |
| Antibody SKU: | PACO34778 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Escherichia coli |
| Immunogen: | Recombinant Escherichia coli Holliday junction ATP-dependent DNA helicase RuvA protein (1-203AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA. |
| Synonyms: | Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12), ruvA |
| UniProt Protein Function: | The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA. |
| UniProt Protein Details: | |
| NCBI Summary: | Binds Holliday junction as two tetramers (an octamer) and each tetrameric half recruits one RuvB hexameric helicase. [More information is available at EcoGene: EG10923]. RuvABC is an enzymatic complex which functions in recombination pathways to by binding to recombinational junctions and catalyzing strand cleavage and branch migration. [More information is available at EcoCyc: RUVA]. |
| UniProt Code: | P0A809 |
| NCBI GenInfo Identifier: | 16129814 |
| NCBI Gene ID: | 946369 |
| NCBI Accession: | NP_416375.1 |
| UniProt Secondary Accession: | P0A809,P08576 |
| UniProt Related Accession: | P0A809 |
| Molecular Weight: | 22,086 Da |
| NCBI Full Name: | component of RuvABC resolvasome, regulatory subunit |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | ruvA |
| NCBI Official Synonym Symbols: | ECK1862; JW1850 |
| NCBI Protein Information: | component of RuvABC resolvasome, regulatory subunit |
| UniProt Protein Name: | Holliday junction ATP-dependent DNA helicase RuvA |
| UniProt Synonym Protein Names: | |
| Protein Family: | Holliday junction ATP-dependent DNA helicase |
| UniProt Gene Name: | ruvA |
| UniProt Entry Name: | RUVA_ECOLI |
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