rtcB Antibody (PACO34526)
- SKU:
- PACO34526
- Product Type:
- Antibody
- Reactivity:
- Bacteria - Escherichia coli
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | rtcB Antibody (PACO34526) |
| Antibody SKU: | PACO34526 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Escherichia coli |
| Immunogen: | Recombinant Escherichia coli RNA-splicing ligase RtcB protein (1-408AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester. |
| Synonyms: | RNA-splicing ligase RtcB (EC 6.5.1.-), rtcB, yhgL |
| UniProt Protein Function: | RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester, a step that requires GTP (PubMed:21224389, PubMed:22730297). Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-PO4 (or cyclic-PO4) and 5'-OH ends that cannot be sealed by classical DNA ligases (PubMed:24218597). |
| UniProt Protein Details: | |
| NCBI Summary: | RtcB has similarity to proteins found in Eucarya, Bacteria, and Archaea . [More information is available at EcoCyc: G7751]. |
| UniProt Code: | P46850 |
| NCBI GenInfo Identifier: | 16131295 |
| NCBI Gene ID: | 947929 |
| NCBI Accession: | NP_417879.1 |
| UniProt Secondary Accession: | P46850,P76690, Q2M785 |
| UniProt Related Accession: | P46850 |
| Molecular Weight: | |
| NCBI Full Name: | RNA-splicing ligase |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | rtcB |
| NCBI Official Synonym Symbols: | ECK3407; JW3384; yhgL |
| NCBI Protein Information: | RNA-splicing ligase |
| UniProt Protein Name: | RNA-splicing ligase RtcB |
| UniProt Synonym Protein Names: | |
| Protein Family: | RNA-splicing ligase |
| UniProt Gene Name: | rtcB |
| UniProt Entry Name: | RTCB_ECOLI |
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