RRAD Antibody (PACO23803)
- SKU:
- PACO23803
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RRAD Antibody (PACO23803) |
| Antibody SKU: | PACO23803 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from internal of human RAD. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HeLa cells, HepG2 cells and MCF-7 cells, using RAD antibody. |
 | Immunofluorescence analysis of A549 cells, using RAD antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human heart tissue using RAD antibody. |
| Background: | May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane By similarity. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. |
| Synonyms: | GTP-binding protein RAD; RAD; RAD1; RAS associated with diabetes; |
| UniProt Protein Function: | RRAD: a small G protein of the RGK family. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Interacts with calmodulin preferentially in the inactive, GDP-bound form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Protein type: G protein, monomeric, RGK; G protein; G protein, monomericChromosomal Location of Human Ortholog: 16q22Cellular Component: plasma membraneMolecular Function: calmodulin binding; GTPase activity; protein binding; GTP bindingBiological Process: metabolic process; small GTPase mediated signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P55042 |
| NCBI GenInfo Identifier: | 192807327 |
| NCBI Gene ID: | 6236 |
| NCBI Accession: | NP_001122322.1 |
| UniProt Secondary Accession: | P55042,Q96F39 |
| UniProt Related Accession: | P55042 |
| Molecular Weight: | 33,245 Da |
| NCBI Full Name: | GTP-binding protein RAD |
| NCBI Synonym Full Names: | Ras-related associated with diabetes |
| NCBI Official Symbol: | RRAD |
| NCBI Official Synonym Symbols: | RAD; RAD1; REM3 |
| NCBI Protein Information: | GTP-binding protein RAD; ras associated with diabetes; RAS (RAD and GEM) like GTP binding 3 |
| UniProt Protein Name: | GTP-binding protein RAD |
| UniProt Synonym Protein Names: | RAD1; Ras associated with diabetes |
| Protein Family: | GTP-binding protein |
| UniProt Gene Name: | RRAD |
| UniProt Entry Name: | RAD_HUMAN |
| Antibodies |
| RRAD Antibody (PACO01393) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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