Antibody Name:	RRAD Antibody (PACO18859)
Antibody SKU:	PACO18859
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human RRAD

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18859(RRAD Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18859(RRAD Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The protein may be important in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. As regulator of voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway and phosphorylation and activation of CAMK2D. Mostly expressed in the heart and muscle of type II diabetic humans. Also found in the skeletal muscle, lung and adipose tissue. Lesser amounts in placenta and kidney.

Synonyms:

Ras-related associated with diabetes

UniProt Protein Function:	RRAD: a small G protein of the RGK family. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Interacts with calmodulin preferentially in the inactive, GDP-bound form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Protein type: G protein, monomeric, RGK; G protein; G protein, monomericChromosomal Location of Human Ortholog: 16q22Cellular Component: plasma membraneMolecular Function: calmodulin binding; GTPase activity; protein binding; GTP bindingBiological Process: metabolic process; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
UniProt Code:	P55042
NCBI GenInfo Identifier:	192807327
NCBI Gene ID:	6236
NCBI Accession:	NP_001122322.1
UniProt Secondary Accession:	P55042,Q96F39
UniProt Related Accession:	P55042
Molecular Weight:	33,245 Da
NCBI Full Name:	GTP-binding protein RAD
NCBI Synonym Full Names:	Ras-related associated with diabetes
NCBI Official Symbol:	RRAD
NCBI Official Synonym Symbols:	RAD; RAD1; REM3
NCBI Protein Information:	GTP-binding protein RAD; ras associated with diabetes; RAS (RAD and GEM) like GTP binding 3
UniProt Protein Name:	GTP-binding protein RAD
UniProt Synonym Protein Names:	RAD1; Ras associated with diabetes
Protein Family:	GTP-binding protein
UniProt Gene Name:	RRAD
UniProt Entry Name:	RAD_HUMAN